hrp0084p3-1185 | Thyroid | ESPE2015

Neonatal Hyperthyroidism with Craniolacunia

Igaki Junko , Inoue Fumitaka , Fujiu Tohru , Hatakeyama Shinitsu

Background: Overt neonatal hyperthyroidism is estimated to occur in 1–2% of offspring of pregnant women with Graves’ disease. Preterm delivery, enhancement of bone include advanced bone age, craniosynostosis, and microcephaly may be present. Ventriculomegaly and hydrocephalus may present rarely, and just three cases were reported previously. Craniosynostosis is a risk factor for delayed cerebral development, hydrocephalus, and psychomotor retardation. Craniolacunia (...

hrp0084p2-214 | Bone | ESPE2015

TmP/GFR is a Useful Marker in Making a Clinical Diagnosis of X-Linked Hypophosphataemic Rickets Caused by the PHEX Gene Mutation

Takeda Ryojun , Miyai Kentaro , Takagi Masaki , Goto Masahiro , Ariyasu Daisuke , Izawa Masako , Igaki Junko , Suzuki Eri , Nakamura Yoshie , Hasegawa Yukihiro

Background: The clinical diagnosis of x-linked hypophosphatemic (XLH) rickets is based on a number of biochemical observations. These include a reduction in the percentage of tubular reabsorption of phosphate (%TRP), and in the maximal tubular phosphate reabsorption capacity corrected for glomerular filtration rate (TmP/GFR). However, it is important to maintain sufficient renal blood flow in order to accurately calculate TmP/GFR.Objective: The aims of t...